The "Principles of Biomanufacturing" course requires an estimated time commitment of 3-5 hours of work per week. This includes activities such as attending classes, completing assignments, and engaging with course materials. The course is designed to be flexible and self-paced, allowing participants to manage their own schedules within the given time frame. It's important to note that the actual time required may vary depending on individual learning styles and the level of engagement with the course content.